One region had gotten a little tender and slightly pink over time, nothing dramatic but enough that I noticed. I decided to stop using that area entirely and let it recover, and I brought it up at my next check-in with my provider so it was on their radar.
The tenderness settled over a couple of weeks once I left it alone. I'm sharing this only as a personal account — I'm not suggesting a rotation scheme for anyone, because that's exactly the kind of thing to work out with a clinician who knows your situation.
What I'm actually interested in: how do others notice early that an area needs a break, before it becomes a real problem? Curious what subtle signs people have learned to pay attention to.