Dihexa — is there any human data at all, or is it entirely preclinical?

As far as I've been able to find, it's essentially all preclinical — cell culture and rodent models, with the mechanism tied to HGF/c-Met and dampened Alzheimer's models. The "seven orders of magnitude more potent than BDNF" line traces to that lab's early characterization, and it's about a specific in-vitro effect, not a demonstrated human cognitive outcome.

So: genuinely interesting molecule, real published mechanism work, zero human efficacy/safety trials that I know of. That last part should weigh heavily. "Promising in mice" is where the vast majority of neuro compounds quietly die.

That's clarifying and honestly a little sobering. The potency-vs-BDNF number gets thrown around like it's a human result. Appreciate you pinning down that it's an in-vitro characterization.

The other half of "no human data" that people skip is that it also means no human safety data — a compound that potently drives synaptogenesis and touches c-Met signaling is exactly the kind of thing where unknown long-term effects aren't a formality. Not fearmongering, just: preclinical means we don't know, in both directions. Anyone thinking about their own health here really should be talking to a professional, not a forum.